In QTP, We can replicate device events, i.e keyboard and mouse operation using the below line of code.
Setting.WebPackage("ReplayType") = 2
By default, value of the Setting is 1, in which UFT interacts with application using the browser through DOM.
Setting.WebPackage("ReplayType") = 1
In case, you are not able to perform click or operation on an element in the page, please give a try by providing setting:
Setting.WebPackage("ReplayType") =2